Biological Models
71 Results were found on Technologies
Sub Category Name
Development of Improved Peptide Inhibitors of the HIF/PHD Interaction – Anemia and HIF – Related Diseases
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
A Computational Based Approach For Designing Plasmids’ Copy Number
We used plasmids in any biotechnological objective (both in the academia and in the industry) and in all model organisms. For example, plasmids are used in fields such as FoodTech, pharma, agriculture, etc. Currently, researchers chose between two possibilities: high copy plasmid (e.g. 500 copies) and low copy plasmid (e.g. 10 copies). However, the ability […] Read More >
A Dedicated Hardware for Accelerating Whole Cell Simulations of mRNA Translation for Various Biotechnological Pharma Applications
Gene expression (is a fundamental process defining all type of life where information encoded in the genetic material is used for generating proteins. Gene expression is a multi-steps process mediated by millions of intracellular biological machines (e.g. RNA polymerases, transcription factors, ribosomes, tRNAs, miRNAs), with complex interactions among them. Recently, intracellular biophysical simulations of gene […] Read More >
A Generic Approach Constructing an Evolutionary Stable Genetic Circuit
Any genetic circuit engineered in any organism will cause a huge metabolic load on its host, compiling the organism to manufacture numerous proteins against his own benefit thus greatly decreasing its fitness. Random mutations that arise during normal DNA replication or during DNA damage repair dictate that it’s unavoidable outcome that the genetic circuit will […] Read More >
Deep Cell-Type Deconvolution From Bulk Gene Expression Data
It is becoming clear that bulk gene expression measurements represent an average over very different cells. Elucidating the expression and abundance of each of the encompassed cells is key to disease understanding and precision medicine approaches. A first step in any such deconvolution is the inference of cell type abundances in the given mixture. To […] Read More >
Epitope Based Vaccines for Flaviviruses
Flaviviridae are a family of positive, single-stranded enveloped RNA viruses that are typically transmitted to humans via mosquitoes and ticks. Yellow Fever virus, West Nile virus and Dengue virus are examples of human Flavivirus pathogens. Dengue virus has 4 serotypes, and getting infected by one serotype, does not protect against the other three. Moreover, pre-infection […] Read More >
Designing Novel Protein-protein Interaction Modulators with Generative Models
UNMET NEED• Protein-protein interactions (PPIs) are essential components of all cell signaling pathways and important therapeutic targets. However, the design of PPI modulators, especially in the form of small molecules, remains a major challenge.• Interfering with PPIs is especially challenging when one of the interactors is a disordered protein (i.e., with no stable structure).• Peptides, […] Read More >
Repurposing FDA-Approved Drugs for the Treatment of Aniridia
Aniridia is a panocular disease causing progressive severe visual impairment and blindness. The disease is characterized by abnormal development of almost all eye structures, caused by dominantly inherited heterozygous mutations in primarily the PAX6 gene. Although aniridia is a developmental disorder, corneal opacification begins late in childhood, leaving a large time window for therapy. Unfortunately, […] Read More >
Culturing a plurality of cell types on a 3D-printed microfluidic chip
Organ-on-a-Chip platforms provide rich opportunities to observe interactions between different cell types under in vivo-like conditions. Co-culturing and the application of flow and other mechanical forces organoids, mimic 3D tissue structure and greatly enrich the data collection from such platforms. ‘Insert-chip’ is a cost-efficient, reusable, modular organ-on-a-chip platform that allows co-culturing and overcome scientific data […] Read More >
Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions
ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >
