Biological Models
71 Results were found on Technologies
Sub Category Name
Self Assembled Peptide Hydrogel
The Technology A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed. SAPH is a safe, self-assembled, biocompatible, remarkably strong hydrogel with modulated stability that is suitable for various medicinal and cosmetic applications. SAPH is based on the highly efficient self-assembly of the short aromatic peptides diphenylalanine. The discovery and development of SAPH is the […] Read More >
Computational Platform for Enhancing Gene Expression for Increased Protein Yield and Viral Titer
Technology Deciphering Gene Expression Code – We perform large-scale analyses of genomic data to discern the rules behind the various aspects of gene expression encoded in the transcript. Computational Modeling of Gene Expression – We develop predictive computational models to mathematically analyze and simulate the different stages of gene expression, focusing on gene translation. Engineering […] Read More >
Molecular Classification of Inflammation and Uses for Personalized Therapy
Our work is focused on decoupling between four inflammatory molecular states: i. Disease tolerance activity. Maintenance of health in the presence of stress, injury, infection. Healing through tissue repair and renewal mechanisms. ii. Antimicrobial activity. Detects, neutralizes, and eliminates the invading pathogen (“resistance”). iii. Metabolic status. Reflects the abnormal cardiometabolic status related to hypertension, diabetes […] Read More >
Methods of Treating Diseases Associated with Polyalanine Expansion Mutations
The invention describes the inhibition of ubiquitin like modifier activating enzyme 6 (UBA6) by disease-causing polyalanine expanded mutant proteins in a variety of cell types. Polyalanine-expanded proteins can interact with UBA6 and inhibit UBA6-mediated protein degradation of downstream targets, such as the neurodevelopmental E3-ubiquitin ligase E6-AP. Ectopic administration of vectors expressing UBA6 in patient cells […] Read More >
Tomato Plants with Broad-Spectrum Pathogen Resistance
Plants rely on innate immunity to perceive and ward off microbes and pests, and are able to overcome many invading microorganisms. Even so, pathogens overcome plant defenses, posing a persistent threat to crop and food security worldwide, raising the need for agricultural products with broad, efficient resistance. The combined goal of several projects in our […] Read More >
Development of a Biological Safe Anti-Candida Agent for the Treatment of Denture Stomatitis
UNMET NEED● Denture stomatitis is a common form of oral candidiasis afflicting according to some reports up to 65% of dentures wearers.● Current treatments are based on toxic chemical agents and are non-effective.● Ani candida solution can be extended towards a broad range of other indications. Treating denture stomatitis holds clinical and patient-related significance. Firstly, […] Read More >
A Cytoskeletal Protein Predicts Disease Incidence, Progression, and Prognosis
Brain tumors comprise over one hundred types of masses, differing in location; patient age; molecular, histological, and immunohistochemical characteristics; prognosis and treatment. Glioma tumors originate from neuroglia, cells supporting the brain. Palladin, a structural protein widely expressed in mammalian tissues, has a pivotal role in cytoskeletal dynamics and motility in health and disease. Palladin is […] Read More >
Low Frequency Nanobubbles-Enhanced Ultrasound Mechanotherapy for Noninvasive Cancer Surgery
A unique theranostic ultrasound-based technology for low-energy mechanical ablation of tissues. Noninvasive ultrasound surgery can be achieved using focused ultrasound to locally affect the targeted site without damaging intervening tissues. Mechanical ablation and histotripsy use short and intense acoustic pulses to destroy the tissue via a purely mechanical effect. Here we show that coupled with […] Read More >
Apparently Silent Mutations That Affect Splicing in Cancer and Other Diseases
Many mutations that cause cancer and other diseases may not be detected since they look like silent mutations that do not change the encoded proteins. One fundamental mechanism that apparently silent mutations can severely disrupt is alternative splicing. We introduce a tool that scores mutations based on models of proteomes generated using aberrant splicing predictions. […] Read More >
Models for Protein Levels Optimization in Chloroplasts Based on mRNA-rRNA Folding and Interactions
Chloroplasts which have evolved from an ancestral bacterium can be the target very efficient expression of heterologous protein with huge economical potential. However, translation in chloroplasts, which have evolved from an ancestral bacterium is not well understood and currently there is no generic quantitative model related to these aspects in the chloroplast. The patent includes […] Read More >
