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75 Results were found on Technologies
Sub Category Name
A Cytoskeletal Protein Predicts Disease Incidence, Progression, and Prognosis
Brain tumors comprise over one hundred types of masses, differing in location; patient age; molecular, histological, and immunohistochemical characteristics; prognosis and treatment. Glioma tumors originate from neuroglia, cells supporting the brain. Palladin, a structural protein widely expressed in mammalian tissues, has a pivotal role in cytoskeletal dynamics and motility in health and disease. Palladin is […] Read More >
Low Frequency Nanobubbles-Enhanced Ultrasound Mechanotherapy for Noninvasive Cancer Surgery
A unique theranostic ultrasound-based technology for low-energy mechanical ablation of tissues. Noninvasive ultrasound surgery can be achieved using focused ultrasound to locally affect the targeted site without damaging intervening tissues. Mechanical ablation and histotripsy use short and intense acoustic pulses to destroy the tissue via a purely mechanical effect. Here we show that coupled with […] Read More >
Apparently Silent Mutations That Affect Splicing in Cancer and Other Diseases
Many mutations that cause cancer and other diseases may not be detected since they look like silent mutations that do not change the encoded proteins. One fundamental mechanism that apparently silent mutations can severely disrupt is alternative splicing. We introduce a tool that scores mutations based on models of proteomes generated using aberrant splicing predictions. […] Read More >
Models for Protein Levels Optimization in Chloroplasts Based on mRNA-rRNA Folding and Interactions
Chloroplasts which have evolved from an ancestral bacterium can be the target very efficient expression of heterologous protein with huge economical potential. However, translation in chloroplasts, which have evolved from an ancestral bacterium is not well understood and currently there is no generic quantitative model related to these aspects in the chloroplast. The patent includes […] Read More >
Targeting Mitochondrial IGF-1 Receptors as Therapy for Neurodevelopmental Disorders
Neurodevelopmental brain disorders (NDDs) pose an immense burden on both the families of patients and the health and educational systems, without any effective therapies. We propose, based on our novel findings that are supported by recent clinical data, a potential gene therapy strategy that might restore the brain activity of patients to a healthy regime. […] Read More >
Deep Brain Stimulation of Thalamic Nucleus Reuniens as a New Therapeutic Tool to Prevent Neuronal and Cognitive Dysfunctions in Alzheimer’s Disease
We utilize the basic concepts of control theory and an integrative approach which spans brain-state, neural circuit, synaptic and molecular levels to boost cognitive resilience to AD pathology1,2. UNMET NEED There is no efficient, disease-modifying therapy at present for Alzheimer’s disease (AD). Even the most successful, recently FDA approved anti-amyloid drug lecanemab shows a great […] Read More >
Glioblastoma Regression by Regulating Astrocytes’ Immunometabolic Signaling
Malignant brain tumors are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumors, targeting the cancer cells has yet to produce significant advances in treatment OUR SOLUTIONAn alternative strategy is to target […] Read More >
Method for Isolating Oral Mucosa-Derived Mesenchymal Stem Cells for Tissue and Organ Regeneration
Identification and isolation of the mesenchymal stem cells from the general population of oral mucosa-derived cells may further improve regenerative therapies. Using cutting edge technology, we’ve been able to identify the subpopulation of mesenchymal stem cells with superior osteogenic capacity and furthermore, to unveil a list of unique markers to isolate these cells. Our findings […] Read More >
Therapeutic Monoclonal Antibodies to Combat Multidrug-Resistant Pathogenic Bacteria
It is predicted that a failure to address the problem of antibiotic-resistant pathogens will result in the death of 10 million people annually, costing the economy more than 100 trillion dollars by the year 2050. In high-income countries where antibiotics are heavily used in the community and agriculture, the strong selection pressure and non-completed antibiotic […] Read More >
A METHOD FOR ENGINEERING OF PLASMID FOR ORGANISM SPECIFIC EXPRESSION
Automatic designing a plasmid such that it will be expressed only in sub-set of organisms in a microbiomes/community. Current microbiome engineering techniques are usually manually tailored for a specific system and neglect the different interactions between the new genetic information and the bacterial population, turning a blind eye to processes such as horizontal gene transfer, […] Read More >
