198 Results were found on Technologies
Sub Category Name
Mirna for the Treatment of Metastatic Breast Cancer
Metastasis is the primary cause for mortality in breast cancer. We showed that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment. We found that miR-96/miR-182 downregulates Palladin protein levels, thereby reducing breast cancer cell migration and invasion. A hydrogel-embedded, gold-nanoparticle-based delivery vehicle provides efficient local, selective, and sustained release of miR-96/miR-182, markedly […] Read More >
Mapping Transverse Relaxation in Preclinical MRI Scanners
UNMET NEED Accurate quantitative magnetic resonance imaging (qMRI) is gradually becoming indispensable in clinical diagnostics and research. It’s application on preclinical MRI scanners, however, is hampered by the use of strong imaging gradients, which act to increase the effects of molecular diffusion, leading to bias of the measured signals. This inherent bias makes qMRI techniques […] Read More >
Peptide-based biomimetic hydrogels for bone regeneration
A multi-component biomimetic hydrogel scaffolds that will guide the architecture of tissue formation in bone defects. UNMET NEED Regeneration of bone defects is a major clinical challenge worldwide. The main objective is to restore and improve the function of bone tissue by scaffolds, providing a suitable environment for tissue regeneration and repair. An ideal, predictable, […] Read More >
Antibody-Based Biosensor Diagnostic tool for Pathogenic Bacteria Detection
UNMET NEED • The antibiotic resistance crisis, driven by the excessive and inappropriate use of antibiotics, is projected to result in 10 million deaths annually by 2050. Rapid and accurate diagnosis of multi-drug resistant (MDR) bacteria is essential to combat this growing global health threat. • There is a critical need for fast, reliable diagnostic […] Read More >
A Cost-Effective On-Site Cell-Free Biomolecules Manufacturing
ABSTRACT On-site biomolecules production is a need for many applications such as drug screening, personalized therapeutics, remote clinics, and more. CONTRALL is a silicone chip that enables cost-effective production and purification of biomolecules (proteins, Abs, etc.). The technology is especially useful for the on-site production of simple and complex biomolecules, thus surpassing the need for a […] Read More >
Molecular Harvesting with Electroporation for Tissue Profiling
Detecting tumors in unknown locations and Creating molecular maps of therapeutically relevant targets in heterogeneous tumors by molecular harvesting with electroporation. Our vision is to assist physicians to diagnose cancer more precise and help scientists and drug companies develop personalized, targeted therapies. We achieved this by providing tools for accurate spatial molecular mapping of tumors […] Read More >
Label-Free 3D Quantitative Imaging of Live Cells
A method for a real-time visualization and automatic processing for detection and classification of untouched and unstained cells during stain-free imaging flow cytometry and digital pathology using digital holographic microscopy and machine learning. UNMET NEED Most approaches dealing with the identification and characterization of specific cell types rely on using unique antigens or contrast agents. […] Read More >
Scalable Bio-Hydrogen Production; a Novel Green Energy Technology
Molecular hydrogen (H2) is a promising clean energy carrier and a valuable commodity with over 60 million tons produced globally and used in many industrial technologies. The current industrial method of hydrogen production is consuming methane (a high-value fuel) and polluting the environment. Bio-hydrogen production by photosynthetic microbes represents an alternate green energy strategy that […] Read More >
Antibacterial and Antibiofilm Activity of Self-Assembled Nanostuctures
The self-assembly of peptides and functionalized amino acids into supramolecular nanostructures has yielded a wide variety of nanomaterials with numerous biomedical applications. UNMET NEED Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and […] Read More >
Plants Having Increase Tolerance to Drought and Salt Stress
Loss of function mutant of a specific gene in tomato, using CRISR/Cas9 genome editing, that results in plants with increase water use efficiency (WUE), drought and salt tolerance. Combined results from five different analyses demonstrate that the mutant tomatoes display increased WUE due to lower stomata conductance and transpiration while photosynthesis rates and yield are […] Read More >
