198 Results were found on Technologies
Sub Category Name
Dense Speed of Sound Shift Imaging for Ultrasonic Thermometry
During thermal therapeutic applications such as high-intensity focused ultrasound (HIFU), hyperthermia, and cryoablation, it is crucial to monitor internal tissue temperature to provide feedback on the procedure. Non-invasive MRI techniques for thermal monitoring are limited by their availability and cost. Ultrasonic thermometry is an emerging adaptable alternative due to the advantages of ultrasound in accessibility, […] Read More >
Designing Novel Protein-protein Interaction Modulators with Generative Models
UNMET NEED• Protein-protein interactions (PPIs) are essential components of all cell signaling pathways and important therapeutic targets. However, the design of PPI modulators, especially in the form of small molecules, remains a major challenge.• Interfering with PPIs is especially challenging when one of the interactors is a disordered protein (i.e., with no stable structure).• Peptides, […] Read More >
Using Eye-Tracking in VR to Identify Subject Preferences to Optimize Personalization
The implementation of virtual reality (VR) has been spreading in many research fields and healthcare applications. In order to better personalize the presented content, there is a need to identify the subjective experience at each time point. Previous studies with eye-tracking (ET) have demonstrated its links to preferences; therefore, collecting ET data during VR experiences […] Read More >
Spatially Targeted Transfection of Mammalian Cells
Mammalian cell transfection with DNA, RNA, small molecules, and proteins is a widely used molecular biology technique. The primary method of cell transfection is electropermeabilization, which increases the permeability of the cell membrane, allowing chemicals, drugs or DNA to be introduced into the cell. Bulk electroporation has been used for DNA transfection in suspension cells […] Read More >
Anti-Oxidation Agent to be Incorporated Into Cosmetics Leading to More Stable and Longer Shelf-Life Products
Oxidation is the reaction of Oxygen with a wide array of reactants. In cosmetics, product oxidation leads to spoilage of ingredients used in the manufacturing products, the inactivation of oxygen-sensitive enzymes, shortening of product shelf-life, and discolorations of end-product. Self-assembling peptide-based hydrogels are simple hydrogels that can be combined with a wide variety of ingredients […] Read More >
Oxygen-Scavenging Peptide Hydrogel for Enzyme Protection
Unmet Need: • O2-sensitive enzymes like [FeFe]-hydrogenase lose activity within seconds of ambient air exposure, severely limiting their industrial and sustainable energy applications • Lack of passive protection methods: Existing O2 protection technologies require continuous energy investment or complex systems to maintain anaerobic conditions The technology: • FmocFF peptide hydrogel: Self-assembling fluorenyl-methyloxycarbonyl-diphenylalanine forms 3D nanofibrillar […] Read More >
Culturing a plurality of cell types on a 3D-printed microfluidic chip
Organ-on-a-Chip platforms provide rich opportunities to observe interactions between different cell types under in vivo-like conditions. Co-culturing and the application of flow and other mechanical forces organoids, mimic 3D tissue structure and greatly enrich the data collection from such platforms. ‘Insert-chip’ is a cost-efficient, reusable, modular organ-on-a-chip platform that allows co-culturing and overcome scientific data […] Read More >
Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions
ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >
Data Driven Algorithm For Visualizing Myelin in The Human Brain
Quantification of myelin content in the human brain is the key for early disease detection and for assessing treatment response in patients with neurodegenerative diseases. However, it has remained challenging due to lack of a reliable method for probing sub-voxel features from clinical MRI data. We developed a data-driven algorithm that accurately converts clinical MRI […] Read More >
Heterogeneous structures comprising III-V semiconductors and metal oxide dielectrics,and a method of fabrication thereof.
Electron mobility in bulk III-V semiconductors is about an order of magnitude higher than in silicon, which promises much faster nanometer-scale electronics in GaAs-based devices. However, fabrication of metal oxide – semiconductor field effect transistors (MOSFETs), the central element of modern electronics, with III-V semiconductors is hampered for years by the unresolved problem of the […] Read More >
