198 Results were found on Technologies
Sub Category Name
4D Printing of Human Vascularized Cardiac Tissues
Conventional 3D bioprinting cannot reliably generate true capillary-scale networks with precise spatial control under cell‑compatible conditions. This technology introduces a one‑step, multi‑kinetic 4D bioprinting platform that prints multiple cell‑laden bioinks in a single process and then triggers coordinated, selective shrinkage of pre‑designed vessels down to capillary dimensions under physiological conditions. Technology Description A thermo‑responsive, cell‑friendly […] Read More >
High-Performance, Melt-Processed Soy Protein Bioplastics
Introduction: The Imperative to Replace Petroleum Plastics The world faces an environmental crisis driven by the pervasive use of petroleum-based plastics. These materials accumulate as waste, pollute ecosystems, and contribute significantly to greenhouse gas emissions throughout their lifecycle. A fundamental shift is required—moving away from fossil fuel dependence towards high-volume, functional materials derived from renewable, […] Read More >
Magnetic Nanoparticle Theranostic Platform
Many severe diseases are located in deep tissues or behind biological barriers that standard systemic drugs cannot penetrate effectively. This anatomical challenge severely limits therapeutic efficacy for conditions affecting the central nervous system, solid tumors, and other immunologically privileged sites. Systemic therapies (such as chemotherapy) produce severe adverse effects while remaining limited in efficacy due […] Read More >
Targeted Antisense Oligonucleotide Therapy Using Lipid Nanoparticles
Antisense Oligonucleotides (ASOs) are among the fastest-growing classes of therapeutics used to modulate gene expression. Among ASOs, Locked Nucleic Acids (LNAs) are an advanced form of ASO with chemical modifications that enhance their binding affinity and stability (1). As of today, several ASOs have been approved for clinical use, primarily for the treatment of rare […] Read More >
Wearable Sensor Platform for Dynamic Cervical Range of Motion Analysis
Unmet Need Current cervical spine assessment methods suffer from notable limitations in accuracy, reproducibility, and practicality. Universal goniometers (the clinical standard) provide inconsistent measurements of cervical range of motion (CROM) due to operator dependence, trunk stabilization requirements, and restricted testing to mostly upright positions, which prevents reliable assessment during dynamic activities or varied postures. Optical […] Read More >
New Anti-Influenza Virus (FLU) Drug Discovery
Influenza A virus infection is one of the most common respiratory tract diseases in humans. It is the cause of typical seasonal flu and major human pandemics worldwide. According to the World Health Organization (WHO), in October 2023, approximately 3 to 5 million severe influenza cases were reported, resulting in 290,000 to 650,000 deaths worldwide. […] Read More >
Scalable Wet-Etching Technology for High-Resolution MXene Microelectrodes
MXenes are an emerging class of highly conductive, two dimensional materials that combine metallic performance with solution based processing. These properties position MXenes as promising candidates for next generation technologies in microelectronics, sensing, and flexible devices. Despite their potential, widespread adoption has been limited by the lack of a practical and scalable method that can […] Read More >
Cell-Permeable Abiotic Transcription Factor Modulators with Enhanced Stability, Intrinsic Cell Pearmiability, and Specific DNA Binding
Cell-Permeable Miniproteins to target Myc oncoprotein Chemically engineered family of Max-derived transcription factor (TF) analogs (μMax modulators) with intrinsic cell permeability, nanomolar DNA binding, and enhanced stability. These abiotic proteins can directly modulate gene expression driven by Myc TF – offering a therapeutic strategy for drugging the undruggable Myc pathway. Unmet Need TFs, especially Myc, are among the […] Read More >
CRISPR-Cas3 Phage Platform Enabling Precision Gut Delivery of Biotherapeutics
This technology introduces a first-in-class engineered phage platform that delivers proprietary DNA Cargos into targeted E. coli strains of the human gut microbiome. Using CRISPR-Cas3–mediated in-vivo selection, the system converts bacterial populations and drives local production of human biotherapeutics directly inside the gut. The platform achieves durable bacterial trait modification without disrupting microbiome balance and […] Read More >
Agent-Based Modeling of Pedestrian Mobility in the City From Research to Opportunity: Unlocking the Value of Pedestrian Flow Data
Understanding and predicting pedestrian flows across a city is critical for smarter urban planning, infrastructure investment, and business decision-making. Traditional data collection is expensive, fragmented, and limited in scope, making large-scale insights difficult to obtain. Our solution: a city-scale Agent-Based Modeling (ABM) platform that combines high-resolution spatio-temporal and GPS-based walking data with advanced Machine Learning […] Read More >
