198 Results were found on Technologies
Sub Category Name
OGP: Immune-Modulating Cancer Therapy
Osteogenic growth peptide (OGP), a selective CB2 agonist, reduces cancer progression in two models of colon cancer and one model of breast cancer in mice by modulating immune responses. Human genetic data supports the role of CB2 in tumor immunology. UNMET NEED Colon carcinoma and breast cancer are prevalent solid tumors with limited therapies and […] Read More >
Catalytic Depolymerization Technology for Sustainable PLA Recycling
As the world strives toward a circular economy and faces mounting environmental concerns about plastic waste, innovative recycling solutions for bioplastics are urgently required. Polylactic acid (PLA), the most common bioplastic, is widely used in packaging, textiles, disposables, biomedical devices, and more due to its biodegradability and non-toxic degradation. However, current end-of-life solutions for PLA—such […] Read More >
Neural Segmentation of Seeding ROIs for Pre-Surgical Brain Tractography
White matter tractography mapping relies on accurate manual delineation of anatomical seeding regions of interest (sROIs) by neuroanatomy experts, but stringent pre-operative time constraints and limited availability of experts create a critical bottleneck for neuro-surgical planning and navigation. Moreover, the manual segmentation process is labor-intensive and not feasible given the time pressures of pre-surgical planning, […] Read More >
Bedside Manufacturing of Personalized mRNA Vaccines
A microfluidic lab-on-a-chip platform enabling on-demand, bedside production of mRNA vaccines encapsulated in lipid nanoparticles (LNPs). Unlike conventional centralized manufacturing, this integrated system performs cell-free transcription and LNP formulation on a single device, delivering ready-to-use mRNA-LNP vaccines rapidly and efficiently. KEY ADVANTAGES • End-to-end automation: From DNA template to formulated mRNA-LNP in one device • […] Read More >
High-Precision Automated Detection of Interictal Epileptiform Discharges in Intracranial EEG Sleep Data
Interictal epileptiform discharges (IEDs) are critical markers in epilepsy, playing a key role in diagnosis and treatment planning; however, their detection remains labor-intensive, subjective, and lacking standardization—particularly in the context of intracranial EEG (iEEG) during sleep. Most existing automated tools were developed for scalp EEG, leaving a significant gap in validated, scalable solutions for deep […] Read More >
Encapsulation of Hydrogenase via Peptide Self-Assembly for Hydrogen Production
Hydrogen is a clean, renewable energy carrier with vast potential to replace fossil fuels. Biological catalysts called hydrogenases, particularly [FeFe] hydrogenases, can efficiently produce hydrogen (H₂) by catalyzing proton reduction under mild conditions. Harnessing these enzymes in electrochemical systems offers a promising path toward sustainable hydrogen generation. Unmet Need Despite their potential, integrating hydrogenases into […] Read More >
Biocompatible Reinforcement of Cellularized Tissues Using Small Molecule Crosslinkers
Existing chemical crosslinking methods such as UV-based, genipin or enzymatic are often cytotoxic and incompatible with the presence of living cells, or result in inhomogeneous reinforcement (primarily surface over core). Moreover, reinforcing ECM whilst ensuring uniform cell viability and spatial distribution in thick tissues remains challenging, particularly when robust mechanical properties are needed post-fabrication. Technology […] Read More >
Ultrasound-Based Monitoring of Hemostatic Gelation
This novel, noninvasive ultrasound-based method enables real-time monitoring of gelation in hemostatic materials by tracking changes in the speed of sound (SoS) within the material. The system uses advanced image processing (dense optical flow) and acoustic modeling to detect viscosity changes during the transition from liquid to gel. Unmet Need Current wound care solutions lack […] Read More >
Cryoablation Temperature Monitoring with Dense Ultrasonic Speed-of-Sound Shift Imaging
Cryoablation is a minimally invasive procedure that destroys tumors using extreme cold. Monitoring temperature is essential but currently requires invasive probes or MRI, which are risky or expensive. We present a noninvasive, real-time ultrasound-based method that tracks temperature changes by measuring speed-of-sound (SoS) shifts in tissue, using advanced image analysis and acoustic modeling. Unmet Need […] Read More >
Rapid Evolutionary Conservation Mapping with Face Lifted ConSurf
The ConSurf pipeline provides a quick and accurate estimate of the evolutionary conservation profile of proteins, RNA and DNA. Mapping of the conservation profile on AlphaFold models readily reveals functionally important regions, e.g., catalytic and binding sites, which are often conserved. ConSurf is available for academic and commercial use using a web-server, as well as […] Read More >
