198 Results were found on Technologies
Sub Category Name
Rationally Designed Functionalization of Single-Walled Carbon Nanotubes for Real-Time Monitoring of Cholinesterase Activity and Inhibition in Plasma
We employ a fluorometric approach to monitor the activity and inhibition of cholinesterase (CHE) enzymes in blood plasma. We utilize near-infrared (NIR) fluorescent single-walled carbon nanotubes (SWCNTs) as probes strategically functionalized with myristoylcholine (MC), which is a substrate for CHE. The fluorescence intensity of MC-suspended SWCNTs undergoes a significant decrease upon interaction with CHE, attributed […] Read More >
Novel Immuno-Metabolism Pathways to Combat Obesity and Insulin Resistance
Nutritional unbalance develops the obesity led to diabetes and accompanied by insulin resistance is being the epidemics of the 21st century. Inflammation of adipose tissue serves one notable pathway that is driving the development of dysfunctional metabolic state, leading to hyperglycaemia and other pathophysiology complications. Within the adipose tissue, a pivotal role in modulating interactions […] Read More >
Hardware Accelerators for Data Structures
We present the first parallel architecture for a dynamic data-structure for approximate membership (i.e., a filter). The dynamic filter supports insertions, deletions, and approximate membership queries. Our architecture borrows techniques from PRAM emulation to parallelize filters based on two levels of fingerprints. A key component in the architecture is a special-purpose wide-word processor we designed […] Read More >
Development of Improved Peptide Inhibitors of the HIF/PHD Interaction – Anemia and HIF – Related Diseases
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
A Computational Based Approach For Designing Plasmids’ Copy Number
We used plasmids in any biotechnological objective (both in the academia and in the industry) and in all model organisms. For example, plasmids are used in fields such as FoodTech, pharma, agriculture, etc. Currently, researchers chose between two possibilities: high copy plasmid (e.g. 500 copies) and low copy plasmid (e.g. 10 copies). However, the ability […] Read More >
A Parallel Algorithm and Scalable Architecture for Routing in Beneš Networks
Beneš/CLOS architectures are the common scalable interconnection networks widely used in backbone routers, data centers, on-chip networks, multi-processor systems, and parallel computers. Recent advances in Silicon Photonic technology, especially MZI technology, had made Beneš networks a very attractive scalable architecture for optical circuit switches. UNMET NEED Our solutions enable the outstanding improvement of the ability […] Read More >
Print-N-Grip: A Disposable, Compliant, Scalable and One-Shot 3D-Printed Multi-Fingered Robotic Hand
Robotic hands are an important tool for replacing humans in handling toxic or radioactive materials. However, these are usually highly expensive, and in many cases, once they are contaminated, they cannot be re-used. Some solutions cope with this challenge by 3D printing parts of a tendon-based hand. However, fabrication requires additional assembly steps. Therefore, a […] Read More >
A Dedicated Hardware for Accelerating Whole Cell Simulations of mRNA Translation for Various Biotechnological Pharma Applications
Gene expression (is a fundamental process defining all type of life where information encoded in the genetic material is used for generating proteins. Gene expression is a multi-steps process mediated by millions of intracellular biological machines (e.g. RNA polymerases, transcription factors, ribosomes, tRNAs, miRNAs), with complex interactions among them. Recently, intracellular biophysical simulations of gene […] Read More >
A Generic Approach Constructing an Evolutionary Stable Genetic Circuit
Any genetic circuit engineered in any organism will cause a huge metabolic load on its host, compiling the organism to manufacture numerous proteins against his own benefit thus greatly decreasing its fitness. Random mutations that arise during normal DNA replication or during DNA damage repair dictate that it’s unavoidable outcome that the genetic circuit will […] Read More >
Deep Cell-Type Deconvolution From Bulk Gene Expression Data
It is becoming clear that bulk gene expression measurements represent an average over very different cells. Elucidating the expression and abundance of each of the encompassed cells is key to disease understanding and precision medicine approaches. A first step in any such deconvolution is the inference of cell type abundances in the given mixture. To […] Read More >
