245 Results were found on Technologies
Sub Category Name
Caches With Many Ways: 16-way Associativity for the Price of 2-way Associativity
Cache design must meet many conflicting demands: high hit rates, low cost, low power, low latency and high throughput. We propose a novel cache design for 16-way associativity with cost and power consumption like 2-way associativity. UNMET NEED We propose a novel cache design with the following features: • High effective cache capacity • Misses […] Read More >
Grid-To-Belt Automatic Sorter
Sorting involves organizing items according to their common characteristics or destinations. The primary performance metric for a sorting system is the number of items it can process in a given time unit, namely, the system’s throughput. Circular conveyor belts (or similar technologies) segmented into sections are the prevailing technology used for sorting. In such systems, […] Read More >
Restoring Immunity Against GI Cancers
BACKGROUND GI cancers cause over 3.5 million deaths per year globally, accounting for 35% of all cancer-related deaths. Colorectal carcinoma (CRC) is the world’s second leading cause of cancer death. Current immunotherapy treatments for CRC are hamstrung by low response rate, acquired resistance, relapse and severe side effects. ImmuNovation presents a disruptive nanomodular technology utilizing […] Read More >
Discovery of a Virus That Threatens The Rainbow Trout Aquaculture
Rainbow trout (Oncorhynchus mykissis) is a North Pacific salmonid species, which, in the Western hemisphere, is the principal inland-farmed fish. In terms of production, global rainbow trout reached 600,000 tons in 2012; by 2019, it had exceeded 950,000 tons. Recently, we discovered a novel and ongoing disease in farmed rainbow trout, the hallmark of which […] Read More >
New MicroRNAs as Candidates for Depression Therapy
Major depressive disorder (MDD) is a complex, common, and recurrent mental disorder (1). The current first-line treatment for MDD is selective serotonin reuptake inhibitors (SSRIs), which are antidepressant drugs that block serotonin reuptake. Two microRNA (miRNAs) molecules namely miR-30b-5p and miR-101a-3p were found to be downregulated in the raphe nuclei (RN) of mice following chronic […] Read More >
Tailorable Sensors for Enzymatic Activity Based on Single-Walled Carbon Nanotubes with a Responsive Corona of Dendron–Polymer Hybrids
We have developed highly modular amphiphilic polymer-dendron hybrids composed of hydrophobic dendrons and hydrophilic linear polymer (e.g. polyethylene glycol (PEG)) that can be synthesized with a high degree of structural precision for suspending SWCNTs in an aqueous solution. Utilizing the susceptibility of the dendritic block of these amphiphiles toward enzymatic degradation, we demonstrated the ability […] Read More >
Rationally Designed Functionalization of Single-Walled Carbon Nanotubes for Real-Time Monitoring of Cholinesterase Activity and Inhibition in Plasma
We employ a fluorometric approach to monitor the activity and inhibition of cholinesterase (CHE) enzymes in blood plasma. We utilize near-infrared (NIR) fluorescent single-walled carbon nanotubes (SWCNTs) as probes strategically functionalized with myristoylcholine (MC), which is a substrate for CHE. The fluorescence intensity of MC-suspended SWCNTs undergoes a significant decrease upon interaction with CHE, attributed […] Read More >
Novel Immuno-Metabolism Pathways to Combat Obesity and Insulin Resistance
Nutritional unbalance develops the obesity led to diabetes and accompanied by insulin resistance is being the epidemics of the 21st century. Inflammation of adipose tissue serves one notable pathway that is driving the development of dysfunctional metabolic state, leading to hyperglycaemia and other pathophysiology complications. Within the adipose tissue, a pivotal role in modulating interactions […] Read More >
Hardware Accelerators for Data Structures
We present the first parallel architecture for a dynamic data-structure for approximate membership (i.e., a filter). The dynamic filter supports insertions, deletions, and approximate membership queries. Our architecture borrows techniques from PRAM emulation to parallelize filters based on two levels of fingerprints. A key component in the architecture is a special-purpose wide-word processor we designed […] Read More >
Development of Improved Peptide Inhibitors of the HIF/PHD Interaction – Anemia and HIF – Related Diseases
Modern drugs are molecules that interfere with the activity of a specific protein related to a target disease. Within this realm, new molecules capable of interfering with protein-protein interactions (PPIs) are in the heart of modern drug discovery. However, the discovery or de-novo design of new molecules is often hampered by the lack of structural […] Read More >
