245 Results were found on Technologies
Sub Category Name
A Computational Based Approach For Designing Plasmids’ Copy Number
We used plasmids in any biotechnological objective (both in the academia and in the industry) and in all model organisms. For example, plasmids are used in fields such as FoodTech, pharma, agriculture, etc. Currently, researchers chose between two possibilities: high copy plasmid (e.g. 500 copies) and low copy plasmid (e.g. 10 copies). However, the ability […] Read More >
A Parallel Algorithm and Scalable Architecture for Routing in Beneš Networks
Beneš/CLOS architectures are the common scalable interconnection networks widely used in backbone routers, data centers, on-chip networks, multi-processor systems, and parallel computers. Recent advances in Silicon Photonic technology, especially MZI technology, had made Beneš networks a very attractive scalable architecture for optical circuit switches. UNMET NEED Our solutions enable the outstanding improvement of the ability […] Read More >
Print-N-Grip: A Disposable, Compliant, Scalable and One-Shot 3D-Printed Multi-Fingered Robotic Hand
Robotic hands are an important tool for replacing humans in handling toxic or radioactive materials. However, these are usually highly expensive, and in many cases, once they are contaminated, they cannot be re-used. Some solutions cope with this challenge by 3D printing parts of a tendon-based hand. However, fabrication requires additional assembly steps. Therefore, a […] Read More >
Micropatterning Cells and Spheroids in 3D Hydrogels
Control over cell organization within 3D hydrogels, strategically placing cells in specific locations, holds significant potential for engineering tissues with precise and intricate architectures, as well as for advancing drug testing applications. Although methods for micropatterning cells on 2D substrates are well-established and widely accessible, achieving cell micropatterning within biomimetic 3D hydrogels—mimicking the soft cellular […] Read More >
A Dedicated Hardware for Accelerating Whole Cell Simulations of mRNA Translation for Various Biotechnological Pharma Applications
Gene expression (is a fundamental process defining all type of life where information encoded in the genetic material is used for generating proteins. Gene expression is a multi-steps process mediated by millions of intracellular biological machines (e.g. RNA polymerases, transcription factors, ribosomes, tRNAs, miRNAs), with complex interactions among them. Recently, intracellular biophysical simulations of gene […] Read More >
A Generic Approach Constructing an Evolutionary Stable Genetic Circuit
Any genetic circuit engineered in any organism will cause a huge metabolic load on its host, compiling the organism to manufacture numerous proteins against his own benefit thus greatly decreasing its fitness. Random mutations that arise during normal DNA replication or during DNA damage repair dictate that it’s unavoidable outcome that the genetic circuit will […] Read More >
Deep Cell-Type Deconvolution From Bulk Gene Expression Data
It is becoming clear that bulk gene expression measurements represent an average over very different cells. Elucidating the expression and abundance of each of the encompassed cells is key to disease understanding and precision medicine approaches. A first step in any such deconvolution is the inference of cell type abundances in the given mixture. To […] Read More >
Epitope Based Vaccines for Flaviviruses
Flaviviridae are a family of positive, single-stranded enveloped RNA viruses that are typically transmitted to humans via mosquitoes and ticks. Yellow Fever virus, West Nile virus and Dengue virus are examples of human Flavivirus pathogens. Dengue virus has 4 serotypes, and getting infected by one serotype, does not protect against the other three. Moreover, pre-infection […] Read More >
Dense Speed of Sound Shift Imaging for Ultrasonic Thermometry
During thermal therapeutic applications such as high-intensity focused ultrasound (HIFU), hyperthermia, and cryoablation, it is crucial to monitor internal tissue temperature to provide feedback on the procedure. Non-invasive MRI techniques for thermal monitoring are limited by their availability and cost. Ultrasonic thermometry is an emerging adaptable alternative due to the advantages of ultrasound in accessibility, […] Read More >
Designing Novel Protein-protein Interaction Modulators with Generative Models
UNMET NEED• Protein-protein interactions (PPIs) are essential components of all cell signaling pathways and important therapeutic targets. However, the design of PPI modulators, especially in the form of small molecules, remains a major challenge.• Interfering with PPIs is especially challenging when one of the interactors is a disordered protein (i.e., with no stable structure).• Peptides, […] Read More >
