Biological Models
71 Results were found on Technologies
Sub Category Name
COPRUDUCTION OF SUSTAINABLE FOOD & MATERIALS FROM SEAWEED
The Need Global population growth together with enhanced quality of life, in the era of climate change, is expected to cause doubling of the world’s food and energy demand by 2050. Furthermore, there is a strong interest in the replacement of fossil-based industries towards economical, environmentally friendly, and sustainable resource, for food, chemical and energy […] Read More >
Early Detection of Ovarian Cancer
We developed a novel proteomic diagnostic assay for detection of epithelial ovarian cancer, offering: • High sensitivity for early stage disease to increase the likelihood of cure. • High specificity for potential delay of risk-reducing surgical procedure. • Early ovarian cancer diagnosis for all age-groups and risk-groups (i.e., BRCA carriers). THE NEED Over 240,000 new […] Read More >
New Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis
Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria.OUR SOLUTION• We […] Read More >
MAPPING THE SITES OF INTERACTION OF THE SMALL GTPASE RAB12 WITH ITS RILP FAMILY EFFECTOR PROTEINS
We have recently shown that the small GTPase Rab12, which was previously shown to control housekeepingfunctions, such as autophagy and iron regulation1,2, negatively regulates degranulation of mastcells (MCs), by binding and recruiting the RILP-dynein motor complex to the MC secretory granules(SGs), and driving their retrograde transport, thus restricting degranulation3. These results havemarked the Rab12-RILP complex […] Read More >
Mirna for the Treatment of Metastatic Breast Cancer
Metastasis is the primary cause for mortality in breast cancer. We showed that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment. We found that miR-96/miR-182 downregulates Palladin protein levels, thereby reducing breast cancer cell migration and invasion. A hydrogel-embedded, gold-nanoparticle-based delivery vehicle provides efficient local, selective, and sustained release of miR-96/miR-182, markedly […] Read More >
Rapid Detection of Drug Resistance in Patients Suffering from Invasive Fungal Infections
Global epidemics of fungal infections caused by drug resistant pathogens has beenrising sharply in recent decades including the most recently discovered Candida auris(an extensive multi-drug resistant fungal pathogen). The Echioncandin class ofantifungal drugs approved as the first-line treatment of candidaemia, invasivecandidiasis and severe infections caused by pathogenic yeast of the genus Candida,the most prevalent fungal […] Read More >
A Cost-Effective On-Site Cell-Free Biomolecules Manufacturing
ABSTRACT On-site biomolecules production is a need for many applications such as drug screening, personalized therapeutics, remote clinics, and more. CONTRALL is a silicone chip that enables cost-effective production and purification of biomolecules (proteins, Abs, etc.). The technology is especially useful for the on-site production of simple and complex biomolecules, thus surpassing the need for a […] Read More >
Antibacterial and Antibiofilm Activity of Self-Assembled Nanostuctures
The self-assembly of peptides and functionalized amino acids into supramolecular nanostructures has yielded a wide variety of nanomaterials with numerous biomedical applications. UNMET NEED Bacterial biofilm formation on wet surfaces represents a significant problem in medicine and environmental sciences. One of the strategies to prevent or eliminate surface adhesion of organisms is surface modification and […] Read More >
Plants Having Increase Tolerance to Drought and Salt Stress
Loss of function mutant of a specific gene in tomato, using CRISR/Cas9 genome editing, that results in plants with increase water use efficiency (WUE), drought and salt tolerance. Combined results from five different analyses demonstrate that the mutant tomatoes display increased WUE due to lower stomata conductance and transpiration while photosynthesis rates and yield are […] Read More >
Gene Expression for Improved Crop Pproductivity
Enhancing crop productivity by optimizing gene expression in plants, using proprietary and proven computational tools, together with genome base editing capabilities. Tapping into gene expression for improved crop UNMET NEED Crop productivity needs to substantially increase to meet global food and feed demand for a rapidly growing world population. Agricultural technology developers are pursuing a […] Read More >
