Biological Models
51 Results were found on Technologies
Sub Category Name
Therapeutic Vaccine for the Treatment of Cancer
An active cancer vaccine strategy targeting tumor-associated carbohydrate antigens expressed on tumor cells using biomimetic glyconanoparticles generated from unique red blood cells. The resulting sustained immune response inhibits tumor growth. THE NEED While envisioned already in 1891, only a few cancer vaccines have been approved by the FDA thus far. The key barriers to their […] Read More >
3D Bioprinting of Tumor Models for Personalized Drug Screening and Disease Modeling
This technology aims to provide a three-dimensional (3D) bioprinted tumor model based on natural and synthetic polymers containing several types of cells, which resembles cancer tissue. Our 3D-bioprinted tumor model has potential to predict the clinical outcome of a treatment compared to the other existing solutions, which either rely solely on genetic profiling or do […] Read More >
Novel Ionizable Lipids for Delivery of Nucleic Acids (mRNA, DNA, siRNA)
BackgroundChemotherapy treatment is generally accompanied by adverse effects, which can be significantly reduced using site specific, targeted delivery systems, such as antibody-coated LNPs (immuno-LNPs). However due to inter-and intra-tumor heterogeneity targeting with a single targeting moiety is not sufficient in many cases and in others may induce cancer relapse due to the survival of side […] Read More >
A Novel Nanoparticle that Selectively Delivers RNAi Oligonucelotides to Tumors, Preventing Side Effects to Tissues
UNMET NEEDPancreatic cancer numbers among the most aggressive cancers known today. The overwhelming majority of pancreatic cancer patients pass away within just a year of diagnosis. However, a small minority of patients may live several years with the disease. Our findings pinpoint the inverse correlation between a known oncogene (PLK1) and the expression of an […] Read More >
HYDEN (HighlY DEgeNerate primers) – A Software for designing pairs of degenerate primers for a given set of DNA sequences
Overview HYDEN (HighlY DEgeNerate primers) is a program for designing pairs of degenerate primers for a given set of DNA sequences. HYDEN works well for large input sets of genomic sequences (e.g., hundreds of sequences of length 1Kbp). HYDEN is a batch (i.e., command-line, as opposed to graphical interface) program, available for Windows XP (downloadable […] Read More >
Self Assembled Peptide Hydrogel
The Technology A breakthrough Self Assembled Peptide Hydrogel (SAPH) has been developed. SAPH is a safe, self-assembled, biocompatible, remarkably strong hydrogel with modulated stability that is suitable for various medicinal and cosmetic applications. SAPH is based on the highly efficient self-assembly of the short aromatic peptides diphenylalanine. The discovery and development of SAPH is the […] Read More >
Computational Platform for Enhancing Gene Expression for Increased Protein Yield and Viral Titer
Technology Deciphering Gene Expression Code – We perform large-scale analyses of genomic data to discern the rules behind the various aspects of gene expression encoded in the transcript. Computational Modeling of Gene Expression – We develop predictive computational models to mathematically analyze and simulate the different stages of gene expression, focusing on gene translation. Engineering […] Read More >
Methods of Treating Diseases Associated with Polyalanine Expansion Mutations
The invention describes the inhibition of ubiquitin like modifier activating enzyme 6 (UBA6) by disease-causing polyalanine expanded mutant proteins in a variety of cell types. Polyalanine-expanded proteins can interact with UBA6 and inhibit UBA6-mediated protein degradation of downstream targets, such as the neurodevelopmental E3-ubiquitin ligase E6-AP. Ectopic administration of vectors expressing UBA6 in patient cells […] Read More >
Tomato Plants with Broad-Spectrum Pathogen Resistance
Plants rely on innate immunity to perceive and ward off microbes and pests, and are able to overcome many invading microorganisms. Even so, pathogens overcome plant defenses, posing a persistent threat to crop and food security worldwide, raising the need for agricultural products with broad, efficient resistance. The combined goal of several projects in our […] Read More >
Development of a Biological Safe Anti-Candida Agent for the Treatment of Denture Stomatitis
UNMET NEED● Denture stomatitis is a common form of oral candidiasis afflicting according to some reports up to 65% of dentures wearers.● Current treatments are based on toxic chemical agents and are non-effective.● Ani candida solution can be extended towards a broad range of other indications. Treating denture stomatitis holds clinical and patient-related significance. Firstly, […] Read More >
