Biological Models
51 Results were found on Technologies
Sub Category Name
Low Frequency Nanobubbles-Enhanced Ultrasound Mechanotherapy for Noninvasive Cancer Surgery
A unique theranostic ultrasound-based technology for low-energy mechanical ablation of tissues. Noninvasive ultrasound surgery can be achieved using focused ultrasound to locally affect the targeted site without damaging intervening tissues. Mechanical ablation and histotripsy use short and intense acoustic pulses to destroy the tissue via a purely mechanical effect. Here we show that coupled with […] Read More >
Apparently Silent Mutations That Affect Splicing in Cancer and Other Diseases
Many mutations that cause cancer and other diseases may not be detected since they look like silent mutations that do not change the encoded proteins. One fundamental mechanism that apparently silent mutations can severely disrupt is alternative splicing. We introduce a tool that scores mutations based on models of proteomes generated using aberrant splicing predictions. […] Read More >
Models for Protein Levels Optimization in Chloroplasts Based on mRNA-rRNA Folding and Interactions
Chloroplasts which have evolved from an ancestral bacterium can be the target very efficient expression of heterologous protein with huge economical potential. However, translation in chloroplasts, which have evolved from an ancestral bacterium is not well understood and currently there is no generic quantitative model related to these aspects in the chloroplast. The patent includes […] Read More >
Targeting Mitochondrial IGF-1 Receptors as Therapy for Neurodevelopmental Disorders
Neurodevelopmental brain disorders (NDDs) pose an immense burden on both the families of patients and the health and educational systems, without any effective therapies. We propose, based on our novel findings that are supported by recent clinical data, a potential gene therapy strategy that might restore the brain activity of patients to a healthy regime. […] Read More >
Deep Brain Stimulation of Thalamic Nucleus Reuniens as a New Therapeutic Tool to Prevent Neuronal and Cognitive Dysfunctions in Alzheimer’s Disease
We utilize the basic concepts of control theory and an integrative approach which spans brain-state, neural circuit, synaptic and molecular levels to boost cognitive resilience to AD pathology1,2. UNMET NEED There is no efficient, disease-modifying therapy at present for Alzheimer’s disease (AD). Even the most successful, recently FDA approved anti-amyloid drug lecanemab shows a great […] Read More >
Glioblastoma Regression by Regulating Astrocytes’ Immunometabolic Signaling
Malignant brain tumors are the cause of a disproportionate level of morbidity and mortality among cancer patients, an unfortunate statistic that has remained constant for decades. Despite considerable advances in the molecular characterization of these tumors, targeting the cancer cells has yet to produce significant advances in treatment OUR SOLUTIONAn alternative strategy is to target […] Read More >
Method for Isolating Oral Mucosa-Derived Mesenchymal Stem Cells for Tissue and Organ Regeneration
Identification and isolation of the mesenchymal stem cells from the general population of oral mucosa-derived cells may further improve regenerative therapies. Using cutting edge technology, we’ve been able to identify the subpopulation of mesenchymal stem cells with superior osteogenic capacity and furthermore, to unveil a list of unique markers to isolate these cells. Our findings […] Read More >
A-Traumatic Teeth Extraction and Immediate Implant Placement
The global dental services market is expected to reach 554.5 billion USD by 2028, with dental implants dominating the market as R&D in this field continues to excel with better biomaterials, improved designs, and surface modifications. Tooth extraction is a crucial step in dental implants procedure. The standard extraction method is based on mechanical rocking […] Read More >
Therapeutic Targeting of PD-1/PD-L1 blockade by Novel Small-molecule Inhibitors
Interactions between programmed cell death ligand 1 (PD-L1) and programmed cell death protein 1 (PD-1) lead to the evasion of cancer cells from an efficient immune response. The inhibition of PD-L1/PD-1 has prevented or reversed exhausted T cells, thus enhancing antitumor T-cell responses. In fact, immune checkpoint blockade targeting the PD-1 axis has become one […] Read More >
Leveraging Gene Panel Sequencing Data for Mutational Signature Analysis with Applications to Personalized Treatment
UNMET NEED Mutational signatures and their exposures are key to understanding the processes that shape cancer genomes with applications to diagnosis and treatment. Yet current signature analysis approaches are limited to relatively rich mutation data that comes from whole-genome or whole-exome sequencing. Recently, orders of magnitude sparser data sets from gene panel sequencing have become […] Read More >
