Research Tools
75 Results were found on Technologies
Sub Category Name
Designing Novel Protein-protein Interaction Modulators with Generative Models
UNMET NEED• Protein-protein interactions (PPIs) are essential components of all cell signaling pathways and important therapeutic targets. However, the design of PPI modulators, especially in the form of small molecules, remains a major challenge.• Interfering with PPIs is especially challenging when one of the interactors is a disordered protein (i.e., with no stable structure).• Peptides, […] Read More >
Repurposing FDA-Approved Drugs for the Treatment of Aniridia
Aniridia is a panocular disease causing progressive severe visual impairment and blindness. The disease is characterized by abnormal development of almost all eye structures, caused by dominantly inherited heterozygous mutations in primarily the PAX6 gene. Although aniridia is a developmental disorder, corneal opacification begins late in childhood, leaving a large time window for therapy. Unfortunately, […] Read More >
Culturing a plurality of cell types on a 3D-printed microfluidic chip
Organ-on-a-Chip platforms provide rich opportunities to observe interactions between different cell types under in vivo-like conditions. Co-culturing and the application of flow and other mechanical forces organoids, mimic 3D tissue structure and greatly enrich the data collection from such platforms. ‘Insert-chip’ is a cost-efficient, reusable, modular organ-on-a-chip platform that allows co-culturing and overcome scientific data […] Read More >
Novel Anti-Tumor Response treatment targeting ErbB receptors and Nucleolin interactions
ErbBs subfamily receptors are mediators of cell growth signals. They have long been associated with a wide variety of lung, ovarian, colon, breast, prostate, and other carcinomas. Nucleolin is a major nucleolar protein of growing eukaryotic cells and is present on the cell surface of a range of cancers. Recently, a robust oncogenic interaction between […] Read More >
COPRUDUCTION OF SUSTAINABLE FOOD & MATERIALS FROM SEAWEED
The Need Global population growth together with enhanced quality of life, in the era of climate change, is expected to cause doubling of the world’s food and energy demand by 2050. Furthermore, there is a strong interest in the replacement of fossil-based industries towards economical, environmentally friendly, and sustainable resource, for food, chemical and energy […] Read More >
Early Detection of Ovarian Cancer
We developed a novel proteomic diagnostic assay for detection of epithelial ovarian cancer, offering: • High sensitivity for early stage disease to increase the likelihood of cure. • High specificity for potential delay of risk-reducing surgical procedure. • Early ovarian cancer diagnosis for all age-groups and risk-groups (i.e., BRCA carriers). THE NEED Over 240,000 new […] Read More >
New Chemiluminescent Protease Probe for Rapid, Sensitive, and Inexpensive Detection of Live Mycobacterium tuberculosis
Tuberculosis (TB) is a top-ten cause of death worldwide. Successful treatment is often limited by insufficient diagnostic capabilities, especially at the point of care in low-resource settings. The ideal diagnostic must be fast, be cheap, and require minimal clinical resources while providing high sensitivity, selectivity, and the ability to differentiate live from dead bacteria.OUR SOLUTION• We […] Read More >
MAPPING THE SITES OF INTERACTION OF THE SMALL GTPASE RAB12 WITH ITS RILP FAMILY EFFECTOR PROTEINS
We have recently shown that the small GTPase Rab12, which was previously shown to control housekeepingfunctions, such as autophagy and iron regulation1,2, negatively regulates degranulation of mastcells (MCs), by binding and recruiting the RILP-dynein motor complex to the MC secretory granules(SGs), and driving their retrograde transport, thus restricting degranulation3. These results havemarked the Rab12-RILP complex […] Read More >
Mirna for the Treatment of Metastatic Breast Cancer
Metastasis is the primary cause for mortality in breast cancer. We showed that breast cancer metastasis can be prevented by miR-96 or miR-182 treatment. We found that miR-96/miR-182 downregulates Palladin protein levels, thereby reducing breast cancer cell migration and invasion. A hydrogel-embedded, gold-nanoparticle-based delivery vehicle provides efficient local, selective, and sustained release of miR-96/miR-182, markedly […] Read More >
Rapid Detection of Drug Resistance in Patients Suffering from Invasive Fungal Infections
Global epidemics of fungal infections caused by drug resistant pathogens has beenrising sharply in recent decades including the most recently discovered Candida auris(an extensive multi-drug resistant fungal pathogen). The Echioncandin class ofantifungal drugs approved as the first-line treatment of candidaemia, invasivecandidiasis and severe infections caused by pathogenic yeast of the genus Candida,the most prevalent fungal […] Read More >
